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Highly Efficient InBr 3 Catalyzed Michael Addition of Indoles to α , β ‐Unsaturated Esters
Author(s) -
Liu Ping,
Chen Wei,
Ren Kai,
Wang Lei
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190011
Subject(s) - chemistry , catalysis , michael reaction , lewis acids and bases , organic chemistry , selectivity , combinatorial chemistry
A highly efficient synthetic strategy toward Michael addition of indoles to α , β ‐unsaturated esters has been developed using Lewis acid InBr 3 as catalyst. The reactions generated 3‐substituted indoles in high yields with excellent regio‐selectivity in the presence of catalytic amount of InBr 3 under mild reaction conditions. The method is simple, efficient and practical.