Premium
Efficient Synthesis of β ‐Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst
Author(s) -
Mohammad Ali Zolfigol,
Ardeshir Khazaei,
Mohammad Mokhlesi,
Abdolkarim Zare,
Maliheh Safaiee,
Fatemeh DerakhshanPanah,
Hassan Keypour,
Ahmad Ali DehghaniFirouzabadi,
Maria Merajoddin
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180460
Subject(s) - chemistry , ketone , catalysis , acetonitrile , chloride , alkyl , condensation , organic chemistry , aluminium , acetyl chloride , reaction conditions , condensation reaction , physics , thermodynamics
Aluminum chloride (AlCl 3 ) efficiently catalyzes one‐pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β ‐acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. Moreover, by this synthetic method, some novel β ‐acetamido ketones and esters ( i.e . one complex structure) are prepared.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom