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Efficient Synthesis of β ‐Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst
Author(s) -
Mohammad Ali Zolfigol,
Ardeshir Khazaei,
Mohammad Mokhlesi,
Abdolkarim Zare,
Maliheh Safaiee,
Fatemeh DerakhshanPanah,
Hassan Keypour,
Ahmad Ali DehghaniFirouzabadi,
Maria Merajoddin
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180460
Subject(s) - chemistry , ketone , catalysis , acetonitrile , chloride , alkyl , condensation , organic chemistry , aluminium , acetyl chloride , reaction conditions , condensation reaction , physics , thermodynamics
Aluminum chloride (AlCl 3 ) efficiently catalyzes one‐pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β ‐acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. Moreover, by this synthetic method, some novel β ‐acetamido ketones and esters ( i.e . one complex structure) are prepared.