Premium
Molecularly Imprinted Polymer for Solid‐Phase Extraction of Ecteinascidin 743 from Sea Squirt
Author(s) -
Tian Minglei,
Li Shengnan,
Row Kyungho
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180450
Subject(s) - chemistry , extraction (chemistry) , molecularly imprinted polymer , solid phase extraction , chromatography , hexane , methanol , selectivity , organic chemistry , catalysis
Ecteinascidin 743 from sea squirt is one of the most original anti‐tumoral activity compounds, as proven by the Natural Cancer Institute. Ecteinascidin 743 could be obtained with traditional liquid extraction, but it should be purified and separated from the extract. A molecularly imprinted solid‐phase extraction procedure was developed for the selective separation. Ecteinascidin 743 was used as the template and the polymer was synthesized in a methanol environment. Water and n ‐hexane as the washing solvents can eliminate most of the interference. Good linearity and low relative standard deviations (less than 4.39%) justify its continuing development.