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Au(I)‐Catalyzted Synthesis of 5‐Bromodifluoromethyl Pyrazoles from Fluorinated Alkynyl Ketones and Hydrazine
Author(s) -
Li Shan,
Li Zhengke,
Peng Dongjie,
Li Yajun,
Zhu Jiangtao,
Xie Haibo,
Yuan Yafen,
Chen Zixian,
Wu Yongming
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180442
Subject(s) - chemistry , hydrazine (antidepressant) , regioselectivity , catalysis , organic chemistry , combinatorial chemistry , chromatography
Fluorinated alkynyl ketones react with hydrazine to give fluorinated pyrazols in good to excellent yields with Au(I) as catalyst. All the reactions were carried out at room temperature with excellent regioselectivity.