Synthesis of Fluoroalkylated Allylic‐ β ‐hydroxyesters and Fluoroalkylated  β , γ ‐Epoxy Esters from Ethyl 3‐Hydroxy‐4‐pentenoate | Zendy

Fang Xiang | Zendy; Xiong Ying | Zendy; Wang Qiong | Zendy; Zhao Min | Zendy; Wu Fanhong | Zendy

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Synthesis of Fluoroalkylated Allylic‐ β ‐hydroxyesters and Fluoroalkylated β , γ ‐Epoxy Esters from Ethyl 3‐Hydroxy‐4‐pentenoate

Author(s) -

Fang Xiang,

Xiong Ying,

Wang Qiong,

Zhao Min,

Wu Fanhong

Publication year - 2011

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201180437

Subject(s) - chemistry , adduct , triethylamine , dehydrohalogenation , medicinal chemistry , organic chemistry , catalysis

A sequential transformation of fluoroalkylated adducts obtained from ethyl 3‐hydroxy‐4‐pentenoate with fluorinated iodides was reported. The dehydrohalogenation of adducts was favored to give fluoroalkylated unsaturated β ‐hydroxy esters in the presence of triethylamine. And intramolecular S N 2 reaction products, fluoroalkylated β , γ ‐epoxy esters, were obtained in 10% aqueous sodium carbonate solution.

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