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Asymmetric Reduction of 2‐Chloro‐3‐oxo Esters by Transfer Hydrogenation
Author(s) -
Bai Jinjin,
Miao Shifeng,
Wu Yun,
Zhang Yawen
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180419
Subject(s) - chemistry , transfer hydrogenation , catalysis , reduction (mathematics) , hydrogen , medicinal chemistry , asymmetric hydrogenation , organic chemistry , enantioselective synthesis , combinatorial chemistry , ruthenium , geometry , mathematics
Asymmetric reduction of 2‐chloro‐3‐oxo esters was achieved by catalytic transfer hydrogenation using [RuCl 2 ( p ‐cymene)]( S , S )‐TsDPEN as the chiral catalyst and HCOOH‐Et 3 N as the hydrogen source. Moderate to good yields (up to 85%) and good enantioselectivities (up to 98% ee ) were obtained.
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