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Convenient Synthesis of 3,5‐Biscarbamoyl‐pyridine Derivatives
Author(s) -
Wang Xiayun,
Zhu Yiwen,
Zhang Min,
Lu Dongliang,
Qian Qun,
Chen Yali,
Cao Weiguo,
Song Liping,
Deng Hongmei
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180367
Subject(s) - chemistry , pyridine , microanalysis , combinatorial chemistry , organic chemistry , medicinal chemistry
An efficient and convenient method for synthesis of 3,5‐bis‐carbamoyl‐2,6‐dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5‐bis(3′,5′‐dimethyl‐1′‐pyrazolyl‐carbonyl)‐2,6‐dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.