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KAl(SO 4 ) 2 ·12H 2 O (Alum) Catalyzed One‐Pot Three‐Component Synthesis of 2‐Alkyl and 2‐Aryl‐4(3 H )‐quinazolinone under Microwave Irradiation and Solvent Free Conditions
Author(s) -
Mohammadi Ali A.,
Sadat Hossini S. S.
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180344
Subject(s) - chemistry , alum , aryl , quinazolinone , alkyl , catalysis , proton nmr , solvent , organic chemistry , elemental analysis , carbon 13 nmr , microwave irradiation , medicinal chemistry , nuclear chemistry
Twenty 2,3‐disubstituted‐4(3 H )‐quinazolinones were synthesed by one‐pot three‐component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO 4 ) 2 ·12H 2 O (Alum) under microwave irradiation and solvent‐free conditions. 6‐Bromo‐2‐propyl‐3‐ p ‐tolylquinazolin‐4(3 H )‐one ( 4m ), 6‐bromo‐2‐methyl‐3‐phenethylquinazolin‐4(3 H )‐one ( 4n ) and 6‐bromo‐2‐ethyl‐3‐phenethylquinazolin‐4(3 H )‐one ( 4o ) were characterized by IR, 1 H NMR, 13 C NMR and elemental analysis.