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Synthesis of Multi‐substituted Benzamide Derivatives under Microwave Irradiation Conditions
Author(s) -
Jia Runhong,
Peng Juhua,
Ma Ning,
Yan Shu,
Tu Shujiang
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180326
Subject(s) - chemistry , benzamide , microwave irradiation , ethylene glycol , methylamine , combinatorial chemistry , microwave , organic chemistry , catalysis , physics , quantum mechanics
A facile microwave‐assisted synthesis of N ‐[( Z )‐1‐(substituted carbamoyl)‐2‐arylvinyl] benzamide derivatives is accomplished via reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4 H )‐ones with different amines (for example methylamine, cyclopropylamine, para ‐toluidine, phenylamine) in ethylene glycol. This protocol broadens the scope of the reaction for the synthesis of N ‐benzamide derivatives.
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