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One‐pot Combinatorial Synthesis of Benzo[4,5]imidazo‐[1,2‐ a ]thiopyrano[3,4‐ d ]pyrimidin‐4(3 H )‐one Derivatives
Author(s) -
Shen Shide,
Zhang Honghong,
Yang Weihua,
Yu Chenxia,
Yao Changsheng
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180308
Subject(s) - chemistry , acetic acid , aryl , aldehyde , amine gas treating , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , alkyl
A series of novel fused tetracyclic benzo[4,5]imidazo[1,2‐ a ]thiopyrano[3,4‐ d ]pyrimidin‐4(3 H )‐one derivatives were synthesized via the reaction of aryl aldehyde, 2 H ‐thiopyran‐3,5(4 H ,6 H )‐dione, and 1 H ‐benzo[ d ]imidazol‐2‐amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.