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In(OTf) 3 ‐Catalyzed Synthesis of Functionalized 1,5‐Benzodiazepines from o ‐Phenylenediamine and Alkyl Propiolates under Solvent‐Free Reaction Conditions
Author(s) -
Wu Haisheng,
Yang Jin,
Wang Lei
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180307
Subject(s) - chemistry , catalysis , alkyl , environmentally friendly , solvent , reaction conditions , organic chemistry , combinatorial chemistry , ecology , biology
A simple, environmental‐friendly, and practical method for the synthesis of benzodiazepine derivatives through a reaction of substituted o ‐phenylenediamines with alkyl propiolates has been developed. The reactions generated the 1,5‐benzodiazepines in good to excellent yields in the presence of catalytic amount of In(OTf) 3 under solvent‐free reaction conditions.