In(OTf) 3 ‐Catalyzed Synthesis of Functionalized 1,5‐Benzodiazepines from  o ‐Phenylenediamine and Alkyl Propiolates under Solvent‐Free Reaction Conditions | Zendy

Wu Haisheng | Zendy; Yang Jin | Zendy; Wang Lei | Zendy

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In(OTf) 3 ‐Catalyzed Synthesis of Functionalized 1,5‐Benzodiazepines from o ‐Phenylenediamine and Alkyl Propiolates under Solvent‐Free Reaction Conditions

Author(s) -

Wu Haisheng,

Yang Jin,

Wang Lei

Publication year - 2011

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201180307

Subject(s) - chemistry , catalysis , alkyl , environmentally friendly , solvent , reaction conditions , organic chemistry , combinatorial chemistry , ecology , biology

A simple, environmental‐friendly, and practical method for the synthesis of benzodiazepine derivatives through a reaction of substituted o ‐phenylenediamines with alkyl propiolates has been developed. The reactions generated the 1,5‐benzodiazepines in good to excellent yields in the presence of catalytic amount of In(OTf) 3 under solvent‐free reaction conditions.

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