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A New Pyridoxal Derivative for Transamination of N ‐Terminus of Proteins
Author(s) -
Zhang Meijuan,
Zhang Xuemei,
Li Juan,
Guo Qingxiang,
Xiao Qin
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180306
Subject(s) - transamination , chemistry , pyridoxal , derivative (finance) , pyridoxal 5 phosphate , stereochemistry , amino acid , pyridoxal phosphate , biochemistry , phosphate , cofactor , enzyme , financial economics , economics
A new pyridoxal‐5‐phosphate (PLP) derivative FHMDP was developed for the transamination of different peptides with three most hindered amino acid residues (Leu, Ile, Val) as their N‐terminus. Compared to the previously reported reactions of PLP derivatives, the N‐terminus transamination could be accomplished efficiently with the new compound.