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Molecular Iodine Promoted Synthesis of New Pyrido[2,3‐ d ]pyrimidin‐4‐ols
Author(s) -
Wang Xicun,
Liang Junling,
Quan Zhengjun,
Bai Lin
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180294
Subject(s) - chemistry , iodine , tandem , microwave irradiation , aryl , combinatorial chemistry , medicinal chemistry , catalysis , stereochemistry , organic chemistry , materials science , alkyl , composite material
A highly ef?cient synthesis of novel pyrido[2,3‐ d ]pyrimidin‐4‐ols was developed via an iodine‐catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3‐ d ]pyrimidin‐4‐ols were obtained from easily available 2‐amino‐4‐aryl‐6‐arylnicotinamides and benzylic amines with good to excellent yields.

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