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Efficient Multi‐component Synthesis of Highly Substituted Imidazoles Utilizing P 2 O 5 /SiO 2 as a Reusable Catalyst
Author(s) -
Shaterian Hamid Reza,
Ranjbar Mohammad,
Azizi Kobra
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180293
Subject(s) - benzil , chemistry , benzoin , ammonium acetate , catalysis , phosphorus pentoxide , organic chemistry , component (thermodynamics) , amine gas treating , physics , high performance liquid chromatography , thermodynamics
Phosphorus pentoxide supported on silica gel (P 2 O 5 /SiO 2 ) has been used as an efficient and reusable catalyst for the one‐pot pseudo four‐component synthesis of 2,4,5‐trisubstituted imidazoles from benzil or benzoin, aldehydes, and ammonium acetate. It was also used for four‐component preparation of 1,2,4,5‐tetrasubstituted imidazoles from benzil or benzoin, aldehydes, primary amine, and ammonium acetate under thermal solvent‐free conditions. The remarkable features of this new procedure are high conversions, cleaner reaction, simple experimental and work‐up procedures and also the catalyst can be easily separated from the reaction mixture and reused several times without any loss of its activity.