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Eco‐friendly and Efficient Synthesis of 2,3‐Dihydroquinazolin‐4(1 H )‐ones
Author(s) -
Majid Ghashang,
Kobra Azizi,
Hamed MoulaviPordanjani,
Hamid Reza Shaterian
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180290
Subject(s) - chemistry , ammonium acetate , environmentally friendly , ammonium chloride , catalysis , solvent , ferric , organic chemistry , iron(iii) chloride , chloride , one pot synthesis , aldehyde , combinatorial chemistry , high performance liquid chromatography , ecology , biology
A simple and facile method for the synthesis of 2,3‐dihydroquinazolin‐4(1 H )‐ones through the direct cyclocondensation of one‐pot three‐component cyclocondensation of isatoic anhydride, ammonium acetate (or primary amines) and aldehydes; and anthranilamide and aldehydes using silica supported ferric chloride (SiO 2 ‐FeCl 3 ) as catalyst under solvent‐free conditions is described.