Isosteviol‐amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One‐pot Three‐component Mannich Reactions | Zendy

An Yajie | Zendy; Qin Qian | Zendy; Wang Chuanchuan | Zendy; Tao Jingchao | Zendy

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Isosteviol‐amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One‐pot Three‐component Mannich Reactions

Author(s) -

An Yajie,

Qin Qian,

Wang Chuanchuan,

Tao Jingchao

Publication year - 2011

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201180272

Subject(s) - chemistry , mannich reaction , conjugate , catalysis , component (thermodynamics) , amino acid , organic chemistry , combinatorial chemistry , organocatalysis , molecule , enantioselective synthesis , biochemistry , physics , mathematical analysis , mathematics , thermodynamics

Isosteviol‐amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three‐component Mannich reaction with hydroxyacetone as donor molecule. Good yields (up to 98%) and excellent stereoselectivities (up to 97:3 dr and 99% ee ) were achieved in a short reaction time. In addition, s yn ‐ or anti ‐configurations of α ‐hydroxy‐ β ‐amino carbonyl compounds were obtained as main products with different chiral catalysts.

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