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Cyclization of 4,5‐Diamino Pyrazole Derivatives and Their Antibacterial Activities
Author(s) -
Rizk Hala F.,
EIBadawi Mahmoud A.,
Ibrahim Seham A.,
EIBorai Mohamed A.
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180265
Subject(s) - chemistry , glyoxal , thiourea , ethyl chloroformate , chalcone , microwave irradiation , pyrazole , aryl , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , alkyl
Abstract A convenient synthesis of intermediate 4,5‐diamino‐3‐aryl‐1‐phenylpyrazoles 4a – 4c was reported. The different cyclization reactions were carried out with chalcone, 2‐mercaptoacetic acid and p ‐anisialdehyde, ethyl chloroformate, glyoxal and thiourea to afford different N and S containing heterocycles. The reaction conditions were compared by conventional heating and microwave irradiation. The structures of the cyclization products were determined by analytical and spectroscopic data. All the synthesized compounds were screened for antibacterial activities in vitro .