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Silica‐bonded S ‐sulfonic Acid as a Recyclable Catalyst for Synthesis of 2,3‐Dihydroquinazolin‐4(1 H )‐ones
Author(s) -
Niknam Khodabakhsh,
Mohammadizadeh Mohammad Reza,
Mirzaee Salimeh
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201180261
Subject(s) - chemistry , catalysis , ammonium acetate , aldehyde , amine gas treating , organic chemistry , sulfonic acid , ethanol , filtration (mathematics) , ammonium , condensation , solid acid , polymer chemistry , statistics , high performance liquid chromatography , mathematics , physics , thermodynamics
2,3‐Dihydroquinazolin‐4(1 H )‐one derivatives were synthesized via a one‐pot, three component reaction of isatoic anhydride and an aromatic aldehyde with ammonium acetate or primary amine catalyzed by silica‐bonded S ‐sulfonic acid in ethanol at 80°C. The reaction work‐up is simple and the catalyst is easily separated from the products by filtration. The heterogeneous catalyst was recycled for ten runs upon the condensation reaction of isatoic anhydride and 4‐chlorobenzaldehyde with ammonium acetate without losing its catalytic activity.