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Synthesis, Antitumor and Apoptosis Inducing Activities of Novel 5‐Fluorouracil Derivatives of Rare Earth (Sm, Eu) Substituted Polyoxometalates
Author(s) -
Feng Changgen,
Gan Qiang,
Liu Xia,
He Hongyou
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100744
Subject(s) - chemistry , hela , cytotoxicity , apoptosis , rare earth , mtt assay , stereochemistry , nuclear chemistry , medicinal chemistry , in vitro , biochemistry , mineralogy
Abstract Two novel 5‐fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates, K 9 (C 4 H 4 FN 2 O 2 ) 2 Sm(PW 11 O 39 ) 2 ·11H 2 O (FSmPW) and K 9 H(C 4 H 4 FN 2 O 2 )Eu(PW 11 O 39 ) 2 ·11H 2 O (FEuPW) were synthesized and characterized by element analysis, ICP, FT‐IR, 1 H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT‐IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C 4 H 4 FN 2 O 2 H 2 PW 12 O 40 ·8H 2 O, and the IC 50 values of FSmPW and FEuPW are 4.20, 3.49 µmol·L −1 against HeLa cells and 4.62, 7.19 µmol·L −1 against HepG‐2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxicity of polyoxometalates.