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Direct N ‐Arylation of Azaheterocycles with Aryl Halides under Ligand‐free Condition
Author(s) -
Yang Qichao,
Wang Yufang,
Zhang Baoji,
Zhang Mingjie
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100715
Subject(s) - chemistry , aryl , halide , ligand (biochemistry) , catalysis , base (topology) , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematical analysis , biochemistry , alkyl , receptor , mathematics
A simple and efficient CN cross‐coupling method of aryl halides with various heterocycles was reported, by using 10 mol% of CuI as catalyst and 1.2 equiv. NaH as base. Aryl iodides, aryl bromides and many substituted aryl chlorides could efficiently react with heterocycles, providing variety of N ‐arylated products in good to excellent yields. The ligand‐free catalyst system was stable in air and could be readily reused.