Premium
A Facile Approach to Fabricate Water‐soluble Au‐Fe 3 O 4 Nanoparticle for Liver Cancer Cells Imaging
Author(s) -
Liang Zhongshi,
Wu Xianrong,
Xie Yegui,
Liu Shunying
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100692
Subject(s) - nanoparticle , chemistry , surface modification , superparamagnetism , nanotechnology , colloidal gold , iron oxide nanoparticles , transmission electron microscopy , fluorescence , conjugated system , fourier transform infrared spectroscopy , coprecipitation , chemical engineering , materials science , organic chemistry , polymer , physics , magnetization , quantum mechanics , magnetic field , engineering
Au‐Fe 3 O 4 nanoparticles were widely used as nanoplatforms for biologic applications through readily further functionalization. Dopamine (DA)‐coated superparamagnetic iron oxide (SPIO) nanoparticles (DA@Fe 3 O 4 ) have been successfully synthesized using a one‐step process by modified coprecipitation method. Then 2–3 nm gold nanoparticles were easily conjugated to DA@Fe 3 O 4 nanoparticles by the electrostatic force between gold nanoparticles and amino groups of dopamine to afford water‐soluble Au‐Fe 3 O 4 hybrid nanoparticles. A detailed investigation by dynamic light scatting (DLS), transmission electron microscopy (TEM), fourier transform infrared (FT‐IR) and X‐ray diffraction (XRD) were performed in order to characterize the physicochemical properties of the hybrid nanoparticles. The hybrid nanoparticles were easily functionalized with a targeted small peptide A54 (AGKGTPSLETTP) and fluorescence probe fluorescein isothiocyanate (FITC) for liver cancer cell BEL‐7402 imaging. This simple approach to prepare hybrid nanoparticles provides a facile nanoplatform for muti‐functional derivations and may be extended to the immobilization of other metals or bimolecular on SPIO surface.