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Iron‐Promoted Practical One‐Pot Synthesis of 2,5‐Disubstituted Oxazoles
Author(s) -
Chen Songhui,
Bai Donghu,
Shi Feng,
Li Jian,
Li Chunju,
Jia Xueshun
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100683
Subject(s) - chemistry , acetonitrile , aryl , one pot synthesis , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , alkyl
A practical one‐pot protocol for the synthesis of 2,5‐disubstituted oxazoles from 1‐aryl‐2‐nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1‐aryl‐2‐nitroethanones with trimethyl orthoacetate or trimethyl orthobenzoate delivered the corresponding 2,5‐disubstituted oxazoles in moderate to good yields.