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A Facile Synthesis of Enantiomerically Pure ( R )‐6‐Arylbinols
Author(s) -
Wang Wenling,
Long Yuhua,
Zou Zhifu,
Yang Dingqiao
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100679
Subject(s) - chemistry , regioselectivity , yield (engineering) , halogenation , hydrolysis , proton nmr , aryl , reaction conditions , coupling reaction , suzuki reaction , organic chemistry , combinatorial chemistry , catalysis , materials science , alkyl , metallurgy
This work reported a convenient method for the preparation of enantiomerically pure 6‐aryl‐2,2′‐dihydroxy‐1,1′‐binaphthyl derivatives starting from the commercially available ( R )‐2,2′‐hydroxy‐1,1′‐binaphthyl [( R )‐ 1 ] via bromination, hydrolysis and Suzuki cross coupling reaction. This novel synthetic method was characterized with high regioselectivity, simple operation, mild reaction conditions, and excellent yield (up to 73%). On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1 H NMR, 13 C NMR, MS and elementary analysis.
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