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Efficient Synthesis of the Functionalized Spiro[indoline‐3,4′‐pyridine] via Four‐component Reaction
Author(s) -
Sun Jing,
Wu Qun,
Zhang Lijuan,
Yan Chaoguo
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100657
Subject(s) - chemistry , malononitrile , indoline , pyridine , triethylamine , catalysis , combinatorial chemistry , component (thermodynamics) , multi component reaction , scope (computer science) , organic chemistry , base (topology) , mathematical analysis , mathematics , physics , computer science , thermodynamics , programming language
An efficient synthetic procedure for the functionalized spiro[indoline‐3,4′‐pyridine] was developed via the four‐component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity.