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Antimicrobial Aromatic Polyketides from Gorgonian‐Associated Fungus, Penicillium commune 518
Author(s) -
Wang Junfeng,
Liu Peipei,
Wang Yi,
Wang Hui,
Li Jing,
Zhuang Yibin,
Zhu Weiming
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100640
Subject(s) - chemistry , penicillium , gorgonian , antimicrobial , fungus , polyketide , enterobacter aerogenes , stereochemistry , microbiology and biotechnology , escherichia coli , botany , organic chemistry , food science , biology , biochemistry , ecology , coral , gene , biosynthesis , enzyme
Seven new aromatic polyketides, communols A–G ( 1 – 7 ), were isolated and identified from the fermentation broth of Penicillium commune 518, a marine‐derived fungus associated with the Gorgonian, Muricella abnormalis . The new structures of 1 – 7 were determined by spectroscopic analysis and X‐ray single crystal diffraction. Among them, communol D ( 4 ) was the first example of a naturally occurring aromatic polyketide with a sulfoxide group from marine fungi. Compounds 1 , 6 , and 7 all showed moderate antimicrobial activities against Escherichia coli and Enterobacter aerogenes with MIC values of 4.1/16.4, 6.4/25.8, and 23.8/23.8 µmol·L −1 , respectively.