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Facile Synthesis of 3‐Substituted Isoquinolines Derivatives via Microwave‐assisted Tandem Three‐component Coupling Cyclization
Author(s) -
Lin Long,
Wu Qiongyou,
Huang Shaowei,
Yang Guangfu
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100560
Subject(s) - chemistry , tandem , microwave irradiation , amine gas treating , component (thermodynamics) , palladium , catalysis , microwave , copper , coupling (piping) , combinatorial chemistry , organic chemistry , mechanical engineering , materials science , physics , quantum mechanics , engineering , composite material , thermodynamics
A novel three‐component reaction of o ‐bromobenzaldehyde, terminal alkynes and tert ‐butyl amine has been established, which proceeded smoothly to give 3‐substituted isoquinolines in good yields in the presence of palladium/copper catalysts under microwave irradiation.