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Pd(OAc) 2 ‐Catalyzed Tandem Reactions for the Synthesis of Indol‐3‐yl Substituted 1 H ‐Isochromenes and 1,2‐Dihydroisoquinolines
Author(s) -
Wang Huan,
Han Xiuling,
Lu Xiyan
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100390
Subject(s) - chemistry , protonolysis , intramolecular force , tandem , catalysis , intermolecular force , alkyne , imine , medicinal chemistry , palladium , quenching (fluorescence) , combinatorial chemistry , cascade reaction , redox , organic chemistry , molecule , materials science , physics , quantum mechanics , composite material , fluorescence
A Pd(II) catalyzed tandem reaction of o ‐alkynylbenzaldehydes or o ‐alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon‐palladium bond by protonolysis to regenerate the Pd(II) species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.