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Difluoromethylation of O ‐, S ‐, N ‐, C ‐Nucleophiles Using Difluoromethyltri( n ‐butyl)ammonium Chloride as a New Difluorocarbene Source
Author(s) -
Wang Fei,
Huang Weizhou,
Hu Jinbo
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100325
Subject(s) - difluorocarbene , chemistry , reagent , ammonium chloride , nucleophile , ammonium , chloride , medicinal chemistry , organic chemistry , catalysis
Difluoromethyltri( n ‐butyl)ammonium chloride 1 was found to be an effective difluorocarbene reagent for O ‐, S ‐, N ‐, C ‐difluoromethylation under basic conditions. It is particularly remarkable that, when only 1.2 equivalent of reagent 1 was used, the difluoromethylated products were obtained in moderate to excellent yields.
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