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Facile Synthesis of 5‐Trifluoromethyl‐2,4‐disubstituted Oxazoles via a Copper(II)‐Catalyzed and TBHP/I 2 ‐Mediated Tandem Oxidative Cyclization
Author(s) -
Wei Song,
Yu Haigang,
Chen Jie,
Deng Hongmei,
Zhang Hui,
Cao Weiguo
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100281
Subject(s) - chemistry , trifluoromethyl , tandem , catalysis , oxidative phosphorylation , combinatorial chemistry , aryl , copper , medicinal chemistry , organic chemistry , biochemistry , alkyl , materials science , composite material
In the presence of Cu(OAc) 2 ·H 2 O, a variety of 5‐trifluoromethyl‐2,4‐disubstituted oxazoles were easily synthesized via t ‐BuOOH (TBHP)/I 2 ‐mediated tandem oxidative cyclization from readily available starting materials aryl methanamines and α ‐trifluoroacetyl‐substituted ketones or esters under mild conditions. The mechanism was proposed.