Efficient Synthesis of Pyrrolo[2,1‐ a ]isoquinoline and Pyrrolo[1,2‐ a ]quinoline Derivatives via One‐pot Two‐step Metal‐catalyzed Three‐component Reactions | Zendy

Wu Lei | Zendy; Sun Jing | Zendy; Yan Chaoguo | Zendy

Premium

Efficient Synthesis of Pyrrolo[2,1‐ a ]isoquinoline and Pyrrolo[1,2‐ a ]quinoline Derivatives via One‐pot Two‐step Metal‐catalyzed Three‐component Reactions

Author(s) -

Wu Lei,

Sun Jing,

Yan Chaoguo

Publication year - 2012

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201100238

Subject(s) - isoquinoline , chemistry , quinoline , acetylenedicarboxylate , intramolecular force , catalysis , component (thermodynamics) , combinatorial chemistry , coupling reaction , medicinal chemistry , multi component reaction , dimethyl acetylenedicarboxylate , stereochemistry , organic chemistry , cycloaddition , physics , thermodynamics

A sequential one‐pot two‐step reaction for efficient synthesis of pyrrolo[2,1‐ a ]isoquinoline and pyrrolo[1,2‐ a ]quinoline derivatives in good yields has been successfully developed. The reaction included firstly Cu‐catalyzed three‐component reaction of isoquinoline (quinoline), acetylenedicarboxylate and alkynylbenzene and then Pd‐catalyzed intramolecular C(sp)‐C(sp 2 ) coupling reaction of initially formed 1‐alkenyl‐2‐alkynyl‐1,2‐dihydroisoquinoline (1,2‐dihydroquinoline).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research