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Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4‐Methyl‐2‐aminophenol
Author(s) -
Gürbüz Demet,
Cinarli Adem,
Tavman Aydin,
Birteks?z A. Seher
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100237
Subject(s) - chemistry , candida albicans , antimicrobial , proteus mirabilis , staphylococcus aureus , klebsiella pneumoniae , staphylococcus epidermidis , escherichia coli , antibacterial activity , pseudomonas aeruginosa , stereochemistry , microbiology and biotechnology , bacteria , organic chemistry , biochemistry , genetics , gene , biology
A series of N ‐(5‐methyl‐2‐hydroxyphenyl)‐(2/3/4/5‐substituted)‐benzaldimines ( I – XIII ) were synthesized using appropriate synthetic route. Their structures were characterized by FT‐IR, UV‐Visible, ESI‐MS, 1 H‐ and 13 C‐NMR spectroscopic techniques and analytical methods. The crystal structure of N ‐(5‐methyl‐2‐hydroxyphenyl)‐3,4‐dimethoxybenzaldimine ( XIII ) was determined by X‐ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds were examined. Antibacterial activities of the compounds were evaluated against Staphylococcus aureus , Staphylococcus epidermidis , Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa and Proteus mirabilis . Antifungal activities were reported for Candida albicans . Some of the Schiff bases showed considerable antimicrobial activity against S. aureus and C . albicans .