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Efficient Copper(I)‐Catalyzed S‐Arylation of KSCN with Aryl Halides in PEG‐400
Author(s) -
Li Xiaokang,
Yuan Tangjun,
Chen Junmin
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100209
Subject(s) - chemistry , halide , aryl , steric effects , catalysis , medicinal chemistry , copper , peg ratio , combinatorial chemistry , organic chemistry , alkyl , finance , economics
A simple and efficient protocol for CuI‐catalyzed CS bond formation of aryl halides with KSCN to symmetrical diaryl sulfides was reported in PEG‐400 without any other additives. A variety of aryl halides were converted to the corresponding diaryl sulfides in good to excellent yields. The present procedure tolerated a variety of functional groups and the steric hindrance of ortho ‐substituents on aryl halides did not affect the outcome.