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Synthesis and Biological Evaluation of Andrographolide C ‐Glycoside Derivatives as α ‐Glycosidase Inhibitors
Author(s) -
Yan Lin,
Xu Haiwei,
Liu Fengwu,
Zhao Jin,
Liu Hongmin
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100179
Subject(s) - andrographolide , chemistry , glycoside hydrolase , glycoside , stereochemistry , alpha (finance) , potency , combinatorial chemistry , enzyme , biochemistry , in vitro , medicine , construct validity , nursing , patient satisfaction
A series of new andrographolide C ‐glycoside derivatives were synthesized by a facile route. The new compounds showed higher potency than the parent andrographolide evaluated as α ‐glycosidase inhibitors in the preliminary study.