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2‐Chlorotetrafluoroethanesulfinamide Induced Diastereoselective Three‐Component Aminoallylation of Aldehydes
Author(s) -
Liu Lijuan,
Liu Jintao
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100134
Subject(s) - chemistry , stereoselectivity , zinc , titanium , bromide , allyl bromide , component (thermodynamics) , indium , zinc bromide , organic chemistry , medicinal chemistry , catalysis , physics , thermodynamics
The diastereoselective three‐component reaction of aldehydes, allyl bromide, and ( S )‐2‐chlorotetrafluoroethanesulfinamide was achieved in the presence of zinc powder and titanium(IV) isopropoxide. Compared to ( S )‐ tert ‐butanesulfinamide, the reaction used zinc powder instead of indium and better results were obtained with aromatic aldehydes. Moreover, opposite stereoselectivity is observed.