Synthesis and in vitro Antibacterial Activities of 5‐(2,3,4,5‐Tetrahydro‐1 H ‐chromeno[2,3‐ d ]pyrimidin‐5‐yl)pyrimidione Derivatives

A series of novel 5‐(2,3,4,5‐tetrahydro‐1 H ‐chromeno[2,3‐ d ]pyrimidin‐5‐yl)pyrimidione derivatives have been synthesized from substituted salicylaldehydes and barbituric acid or 2‐thiobarbituric acid in water catalyzed by phase transfer catalysis of triethylbenzyl ammonium chloride (TEBA). Elemental analysis, IR, 1 H NMR, and 13 C NMR elucidated the structures of all the newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Escherichia coli , Bacillus subtilis , Staphylococcus aureus , and Pseudomonas aeruginosa . These newly synthesized derivatives exhibited significant in vitro antibacterial activity.