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Synthesis and in vitro Antibacterial Activities of 5‐(2,3,4,5‐Tetrahydro‐1 H ‐chromeno[2,3‐ d ]pyrimidin‐5‐yl)pyrimidione Derivatives
Author(s) -
Cheng Qingfang,
Wang Qifa,
Tan Ting,
Wang Mingxiao,
Chen Na
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100112
Subject(s) - chemistry , bacillus subtilis , antibacterial activity , in vitro , antimicrobial , barbituric acid , catalysis , proton nmr , organic chemistry , combinatorial chemistry , bacteria , biochemistry , genetics , biology
A series of novel 5‐(2,3,4,5‐tetrahydro‐1 H ‐chromeno[2,3‐ d ]pyrimidin‐5‐yl)pyrimidione derivatives have been synthesized from substituted salicylaldehydes and barbituric acid or 2‐thiobarbituric acid in water catalyzed by phase transfer catalysis of triethylbenzyl ammonium chloride (TEBA). Elemental analysis, IR, 1 H NMR, and 13 C NMR elucidated the structures of all the newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Escherichia coli , Bacillus subtilis , Staphylococcus aureus , and Pseudomonas aeruginosa . These newly synthesized derivatives exhibited significant in vitro antibacterial activity.