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Improved Synthesis of 1,3‐Diaryl‐2‐propen‐1‐one Oxime in the Presence of Anhydrous Sodium Sulfate
Author(s) -
Xu Xiaoya,
Li Jitai,
Du Chao,
Song Yali
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201100038
Subject(s) - chemistry , anhydrous , hydroxylamine hydrochloride , oxime , hydroxylamine , yield (engineering) , hydrochloride , sodium sulfate , condensation , sodium , molar ratio , guanidine , organic chemistry , medicinal chemistry , nuclear chemistry , inorganic chemistry , catalysis , materials science , physics , metallurgy , thermodynamics
Synthesis of 1,3‐diaryl‐2‐propen‐1‐one oxime via the condensation of 1,3‐diaryl‐2‐propen‐1‐one with hydroxylamine hydrochloride in the presence of anhydrous sodium sulfate was carried out in refluxing EtOH for 2–4 h in 83%–93% yields. The significant features of the present procedure include higher yield, shorter reaction time, reduced molar ratio of hydroxylamine hydrochloride to substrate, compared to the reported literature method.