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Synthesis of Click‐Chelator via Cu(I)‐Catalyzed Alkyne‐Azide Cycloaddition
Author(s) -
Fu Yang,
Liu Yan,
Fu Xiaoping,
Zou Li,
Li Hua,
Li Ming,
Chen Xingguo,
Qin Jingui
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090368
Subject(s) - chemistry , cycloaddition , alkyne , azide , click chemistry , triazole , pyridine , chelation , catalysis , crystal structure , ligand (biochemistry) , 1,2,3 triazole , combinatorial chemistry , medicinal chemistry , crystallography , organic chemistry , receptor , biochemistry
The click‐ligands based on 1,2,3‐triazole and pyridine unit has been synthesized via Cu(I)‐catalyzed alkyne‐azide cycloaddition from corresponding organic azides and terminal alkynes. The ligand structure was characterized by NMR, IR and elemental analysis as well as single crystal diffractions. The single crystal structure of the complexes from two different ligands coordinating to Cu(II) and Co(II) ions indicated that the N(2) atom in 1,2,3‐triazole unit can act as an efficient donor to metals through the rational molecular design.