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Synthesis, Crystal Structure, Spectroscopic, Electrochemical and Antimicrobial Properties of Cu(II) Complex with the Mixed Ligands of 2,9‐Dimethyl‐1,10‐phenanthroline and 4‐Hydroxypyridine‐2,6‐dicarboxylic Acid
Author(s) -
Derikvand Zohreh,
Talei Gholam Reza,
Aghabozorg Hossein,
Olmstead Marilyn M.,
Azadbakht Azadeh,
Nemati Andya,
Gharamaleki Jafar Attar
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090358
Subject(s) - chemistry , bacillus cereus , hydrogen bond , antimicrobial , square pyramidal molecular geometry , stacking , crystal structure , crystallography , phenanthroline , candida albicans , electrochemistry , single crystal , broth microdilution , stereochemistry , organic chemistry , minimum inhibitory concentration , bacteria , molecule , microbiology and biotechnology , genetics , electrode , biology
A mononuclear Cu(II) complex with mixed ligands, formulated as [Cu(hypydc)(dmp)]·H 2 O (hypydc=4‐hydroxypyridine‐2,6‐dicarboxylate, dmp=2,9‐dimethyl‐1,10‐phenanthroline), was synthesized and well characterized by single crystal X‐ray diffraction analysis, as well as spectroscopic (IR, UV‐Vis), and electrochemical methods. The Cu(II) atom exhibits a distorted square‐pyramidal geometry. Intermolecular OH···O and CH···O hydrogen bonds, π‐π stacking interactions and CH···π interactions seem to be effective in the stabilization of the crystal structure. The complex was also evaluated for its antimicrobial activity using in vitro microdilution methods. Six standard bacteria and a strain of Candida albicans were used for the antimicrobial activities. There was a very strong activity against Candida albicans and significant activities against Enterococcus fecalis , Listeria monocytogenes , Bacillus cereus and Staphylococcus aureus , indicating important biological activities of the complex.