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Effects of Acid and Base on the Inductive Efficiency of Oligonucleotide on the Vesicle Formation from Single‐Chained Cationic Surfactant
Author(s) -
Guo Xia,
Cui Bo
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090353
Subject(s) - chemistry , vesicle , oligonucleotide , cationic polymerization , pulmonary surfactant , amphiphile , base (topology) , dna , hydroxide , biophysics , combinatorial chemistry , biochemistry , inorganic chemistry , organic chemistry , membrane , copolymer , biology , polymer , mathematical analysis , mathematics
Recently, we reported for the first time that oligonucleotide could induce single‐chained cationic surfactant molecules to aggregate into vesicles and the facilitative efficiency of oligonucleotide on vesicle formation was dependent on its size and sequence. In the present paper, we will continue to study the effects of acid and base on the facilitative efficiency of oligonucleotide on vesicle formation. It is found that proton ions show little effect on the facilitative efficiency while hydroxide ions make it decreased. Moreover, the percentage of oligonucleotide involved in vesicle formation in basic solution is much lower than that in acidic solution (which is almost equal to that in water). Since the structures and properties of DNA/amphiphile complex are very important for its application as nonviral gene carrier, this study may provide some helpful information for gene therapy.