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Gallium(III) Iodide‐catalyzed Biginelli‐type Reaction Under Solvent‐free Conditions: Efficient Synthesis of Dihydropyrimidine‐2(1 H )‐one Derivatives
Author(s) -
Li Dapeng,
Mao Haifeng,
An Litao,
Zhao Zhihao,
Zou Jianping
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090338
Subject(s) - chemistry , thiourea , biginelli reaction , aldehyde , ethyl acetoacetate , gallium , urea , iodide , catalysis , organic chemistry , solvent , condensation , physics , thermodynamics
The Biginelli‐type condensation of ethyl acetoacetate/cycloketone, aldehyde and urea/thiourea under solvent‐free condition catalyzed by 10% gallium(III) iodide to form dihydropyrimidine‐2(1 H )‐one derivatives was described. This process offered one way to constructing dihydropyrimidine‐2(1 H )‐ones in good to excellent yields with simple procedure and short reaction time.