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Cu‐Catalyzed Asymmetric Michael Addition of Glycine Derivatives to α , β ‐Unsaturated Malonates
Author(s) -
Hou Xuelong,
Li Qing,
Yao Jun,
Dai Lixin
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090297
Subject(s) - chemistry , michael reaction , glycine , catalysis , organic chemistry , addition reaction , medicinal chemistry , combinatorial chemistry , amino acid , biochemistry
Michael addition of glycine imines with alkylidene and arylidene malonates has been developed using Cu/FcPhox as catalyst, providing corresponding Michael products in high yields with high diastereo‐ and enantioselectivities.
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