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Asymmetric Hydrogenation of Unfunctionalized Enamines Catalyzed by Iridium Complexes of Chiral Spiro N , N ‐Diarylphosphoramidites
Author(s) -
Yan Pucha,
Xie Jianhua,
Zhou Qilin
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090293
Subject(s) - chemistry , iridium , catalysis , aryl , alkyl , asymmetric hydrogenation , organic chemistry , medicinal chemistry , enantioselective synthesis , combinatorial chemistry
Abstract Chiral spiro N,N ‐diarylphosphoramidites were synthesized. These new chiral spiro monophosphoramidites were efficient ligands for iridium‐catalyzed asymmetric hydrogenation of unfunctionalized enamines derived from simple alkyl aryl ketones, providing chiral tertiary amines in good enantioselectivities (up to 90% ee ).