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Studies on Synthesis of the C‐1 to C‐18 Fragment of Pamamycins 607 and 621A
Author(s) -
Ren Guobao,
Wu Yikang
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090280
Subject(s) - chemistry , stereocenter , fragment (logic) , aldol reaction , stereochemistry , chirality (physics) , ketone , malic acid , substrate (aquarium) , block (permutation group theory) , enantioselective synthesis , organic chemistry , catalysis , chiral symmetry , algorithm , physics , oceanography , mathematics , quantum mechanics , quark , geology , computer science , nambu–jona lasinio model , citric acid , geometry
Some efforts directed towards synthesis of the C‐1 to C‐18 fragment of natural antibiotic pamamycins 607 and 621A are disclosed. The nine stereogenic centers in the fragment were installed using a chiral auxiliary‐induced asymmetric aldol reaction, a chiral building block derived from malic acid, or substrate chirality‐induced asymmetric reduction of a ketone carbonyl group.