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Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl‐ β ‐cyclodextrin
Author(s) -
Peng Mingli,
Liu Yanhong,
Zhang Hua,
Cui Yali,
Zhai Gaohong,
Chen Chao
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090223
Subject(s) - chemistry , doxorubicin , aqueous solution , cyclodextrin , titration , nuclear chemistry , fourier transform infrared spectroscopy , chromatography , organic chemistry , chemical engineering , chemotherapy , surgery , medicine , engineering
The photodegradation of doxorubicin (Dox) in the presence of hydroxypropyl‐ β ‐cyclodextrin (HP‐ β ‐CD) was studied; the degradation rate constant in the presence of HP‐ β ‐CD estimated by Lineweaver‐Burk analysis was approximately three times lower than that of free Dox aqueous solution, which shows that HP‐ β ‐CD can enhance the photostability of doxorubicin aqueous solution. The enhancement may be attributed to the inclusion interaction between HP‐ β ‐CD and doxorubicin. The characterization of FTIR, DSC, XRD and fluorescence titration indicates that 1:1 inclusion complex is formed between HP‐ β ‐CD and doxorubicin.
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