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Convenient Synthesis of D ‐Talose from D ‐Galactose
Author(s) -
Xiao Hualing,
Wang Guangfa,
Wang Peng,
Li Yingxia
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090213
Subject(s) - chemistry , galactose , yield (engineering) , aldose , combinatorial chemistry , stereochemistry , organic chemistry , glycoside , materials science , metallurgy
Abstract The rare and expensive D ‐talose was conveniently synthesized from readily available D ‐galactose in four steps with an overall yield of 58%. The key step was the inversion of equatorial 2‐OH of galactose to the axial one by S N 2 reaction under the modified Lattrell‐Dax reaction conditions.