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Synthesis of Novel Spiro Pyrrolidine and Pyrrolizine Derivatives by 1,3‐Dipolar Cycloaddition
Author(s) -
Li Xiaofang,
Zheng Aiting,
Liu Bin,
Yu Xianyong,
Yi Pinggui
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090209
Subject(s) - chemistry , sarcosine , pyrrolidine , isatin , cycloaddition , azomethine ylide , 1,3 dipolar cycloaddition , proline , stereoselectivity , stereochemistry , organic chemistry , amino acid , medicinal chemistry , glycine , catalysis , biochemistry
Abstract The 1,3‐dipolar cycloaddition of azomethine ylides derived from isatin and amino acids viz . sarcosine and proline to 2‐arylmethylidene‐5,6‐dihydroimidazo[2,1‐ b ]thiazol‐3(2 H )‐ones afforded novel spiro pyrrolidines and pyrrolizidines regio‐ and stereoselectively in moderate yields. The products were characterized thoroughly by IR, MS, NMR together with elementary analysis.