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Keggin Heteropolyacid Catalyzed Synthesis of Isoxazolo‐ [5,4‐ d ]pyrimidine‐4,6(5 H ,7 H )‐diones at Room Temperature
Author(s) -
Bamoharram Fatemeh F.,
Roshani Mina,
Heravi Majid M.,
Mahdavi Masoumeh,
Javid Ali,
Emampour Jalal Sh.
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090180
Subject(s) - chemistry , pyrimidine , catalysis , isoxazole , aryl , organic chemistry , quinazoline , medicinal chemistry , stereochemistry , alkyl
Isoxazolo[5,4‐ d ]pyrimidine‐4,6(5 H ,7 H )diones 2a – 2f have been synthesized from the reaction of ethyl 5‐amino‐3‐methyl‐4‐isoxazole carboxylate ( 1 ) with aryl isocyanates in the presence of Keggin heteropolyacid H 3 [PW 12 O 40 ] as a green solid acid catalyst at room temperature in a one‐pot process in good yields.