Premium
Total Synthesis of Cytosporone B
Author(s) -
Huang He,
Zhang Lei,
Zhang Xiaodong,
Ji Xun,
Ding Xiao,
Shen Xu,
Jiang Hualiang,
Liu Hong
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090163
Subject(s) - chemistry , acylation , total synthesis , phenol , friedel–crafts reaction , grignard reaction , ether , organic chemistry , agonist , stereochemistry , biochemistry , receptor , reagent , catalysis
The total synthesis of Cytosporone B, a naturally occurring agonist for Nur77, has been accomplished. The key steps are the sequential Grignard reaction and Lemieux‐van Rudloff oxidation followed by a deprotection of the methyl aromatic ether to phenol and subsequent Friedel‐Crafts acylation.