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Synthesis of Novel Unsymmetric Bisbenzimidazoles
Author(s) -
Mao Zhengzhou,
Wang Zhaoyang,
Mei Wenjie,
Yang Kai
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090152
Subject(s) - chemistry , chloroacetic acid , molecule , elemental analysis , proton nmr , carbon 13 nmr , organic chemistry , combinatorial chemistry
Using chloroacetic acid, p ‐hydroxyl aromatic aldehydes 1 and aromatic diamines 3 as starting materials, novel bisbenzimidazoles 5 with unsymmetric structure were synthesized via aryloxyacetic acid intermediates 2 . Four new intermediates 4 and ten target molecules 5 were characterized by FTIR, 1 H NMR, 13 C NMR, MS and elemental analysis. Different synthetic methods, including one‐pot synthesis and intermittent microwave promotion, were investigated. The research provides a new method and idea for the synthesis of bisbenzimidazoles.