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High Resolution of Racemic Mandelic Acid through a Method of Bubble Fractionation
Author(s) -
Jiao Feipeng,
Li Lin,
Chen Xiaoqing,
Hu Yuehua,
Yang Ling
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090131
Subject(s) - chemistry , mandelic acid , resolution (logic) , fractionation , enantiomer , bubble , chromatography , cyclodextrin , reaction rate constant , chemical reaction , buffer solution , analytical chemistry (journal) , kinetics , organic chemistry , physics , quantum mechanics , artificial intelligence , parallel computing , computer science
A method of bubble fractionation was developed for the resolution of racemic mandelic acid (MA), using 2‐hydroxypropyl‐ β ‐cyclodextrin (HP‐ β ‐CD) as chiral collector. The influences of concentration of HP‐ β ‐CD, reflux equilibriation time, gas flow rate, packing height of column and pH of buffer on resolution performance were investigated, respectively. According to the similar physical behavior of bubble fractionation and chemical reaction processes, the equivalent chemical reaction constant was introduced. The resolution process was preliminarily analyzed by means of kinetics. The results show that the enantiomeric excess of 60.7% can be obtained under the optimal conditions. The process could be regarded as a first order chemical reaction, where the equivalent speed constant was k l =0.00376. This method is helpful for realizing high resolution and linear amplification of device.